Discipline of Physiology

 

Biosketch:

Dr Ngubane holds a PhD degree in Medical Sciences and is currently a Senior Lecturer and Medical Researcher at UKZN’s School of laboratory Medicine and Medical Sciences, in the department of Human Physiology.
Dr Ngubane is an Y NRF rated Medical Physiologist, whose research interests involve establishing alternative management strategies for the treatment of Diabetes Mellitus and Preeclampsia. This includes investigating the effects of hypo and anti-hyperglycaemic agents on Renal, Cardiovascular, Hematological and Hepatic function in metabolic disorders.
Dr Ngubane has in the past 5 years published well over 35 articles in various High Impact Factor Journals and has supervised to completion since 2017, 4 PhD students and 17 Masters students

Recent publications:

B Mbatha, A Khathi, N Sibiya, I Booysen, P Ngubane

(2022) A Dioxidovanadium Complex cis-[VO2 (obz) py] Attenuates Hyperglycemia in Streptozotocin (STZ)-Induced Diabetic Male Sprague-Dawley Rats via Increased GLUT4 and Glycogen …

Evidence-Based Complementary and Alternative Medicine

AM Akinnuga, A Siboto, B Khumalo, NH Sibiya, P Ngubane, A Khathi(2022) Evaluation of the effects of bredemolic acid on selected markers of glucose homeostasis in diet-induced prediabetic rats Archives of Physiology and Biochemistry 128 (2), 306-312

N Sibiya, B Mbatha, C Arineitwe, C Onyekwuluje, P Ngubane, A Khathi (2022) Covid 19 May Limit the Use of Anti-hyperglycemic Agents. Does it Call for the Development of New Anti-hyperglycemic Agents? Current diabetes reviews 18 (3), 77-86

KR Matee, AM Akinnuga, A Siboto, P Ngubane, A Khathi

(2022) Bredemolic acid restores glucose utilization and attenuates oxidative stress in palmitic acid-induced insulin-resistant C2C12 cells Endocrine Regulations 56 (2), 126-133

N Sibiya, N Mzimela, B Mbatha, P Ngubane, A Khathi

(2022) The Insights on Why Diabetes Prevalence May Increase Amid or Post COVID 19 Pandemic.

Current Diabetes Reviews

AM Sosibo, NC Mzimela, PS Ngubane, A Khathi

(2021) Prevalence and correlates of pre-diabetes in adults of mixed ethnicities in the South African population: a systematic review and meta-analysis protocol BMJ open 11 (10), e048266

B Mkhize, P Mosili, P Ngubane, N Sibiya, A Khathi

(2021) Diet-induced prediabetes: Effects on the systemic and renal renin-angiotensin-aldosterone system

NC Mzimela, PS Ngubane, A Khathi – 2021

(2021)The Haemolytic Changes During Progression of Pre-Diabetes to Type 2 Diabetes in a High-Fat High-Carbohydrate Diet-Induced Pre-Diabetic Rat Model

B Mbatha, A Khathi, N Sibiya, I Booysen, P Mangundu, P Ngubane (2021) Anti-hyperglycaemic effects of dioxidovanadium complex cis-[VO₂(obz)py] avert kidney dysfunction in streptozotocin-induced diabetic male Sprague–Dawley rats

Canadian journal of physiology and pharmacology 99 (4), 402-410

N Xulu, P Ngubane, A Khathi, I Booysen, N Sibiya

(2021) Heamanetic Effects of a Dioxidovanadium (V) Complex in STZ-Induced Diabetic Male Sprague Dawley Rats

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 14, 4321

S Maikoo, D Makayane, IN Booysen, P Ngubane, A Khathi

(2021) Ruthenium compounds as potential therapeutic agents for type 2 diabetes mellitus European Journal of Medicinal Chemistry 213, 113064

B Mbatha, A Khathi, N Sibiya, I Booysen, P Mangundu, P Ngubane (2021) Cardio-protective effects of a dioxidovanadium (V) complex in male sprague–dawley rats with streptozotocin-induced diabetes

BioMetals 34 (1), 161-173

M Gamede, L Mabuza, P Ngubane, A Khathi (2021) Preventing the onset of diabetes-induced chronic kidney disease during prediabetes: The effects of oleanolic acid on selected markers of chronic kidney disease in a diet …

Biomedicine & Pharmacotherapy 139, 111570

LP Mabuza, MW Gamede, S Maikoo, IN Booysen, PS Ngubane, A Khathi (2020) Amelioration of risk factors associated with diabetic nephropathy in diet-induced pre-diabetic rats by an uracil-derived diimine ruthenium (II) compound

Biomedicine & Pharmacotherapy 129, 110483

M Gamede, L Mabuza, P Ngubane, A Khathi

(2020) Plant-derived oleanolic acid ameliorates markers of subclinical inflammation and innate immunity activation in diet-induced pre-diabetic rats Therapeutic Advances in Endocrinology and Metabolism 11, 2042018820935771

AM Akinnuga, A Siboto, B Khumalo, NH Sibiya, P Ngubane, A Khathi(2020) Ameliorative effects of Bredemolic acid on markers associated with renal dysfunction in a diet-induced Prediabetic rat model Oxidative Medicine and Cellular Longevity

P Mosili, BC Mkhize, P Ngubane, N Sibiya, A Khathi (2020)

The dysregulation of the hypothalamic–pituitary–adrenal axis in diet-induced prediabetic male Sprague Dawley rats

Nutrition & Metabolism 17 (1), 1-12

AM Akinnuga, A Siboto, B Khumalo, NH Sibiya, P Ngubane, A Khathi (2020) Bredemolic acid ameliorates selected liver function biomarkers in a diet-induced prediabetic rat model

Canadian Journal of Gastroenterology and Hepatology

M Gamede, L Mabuza, P Ngubane, A Khathi

(2019) Plant-derived oleanolic acid ameliorates markers associated with non-alcoholic fatty liver disease in a diet-induced pre-diabetes rat model Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 12

M Gamede, L Mabuza, P Ngubane, A Khathi (2019) Plant-derived oleanolic acid (OA) ameliorates risk factors of cardiovascular diseases in a diet-induced pre-diabetic rat model: effects on selected cardiovascular risk factors

Molecules 24 (2), 340

LP Mabuza, MW Gamede, S Maikoo, IN Booysen, PS Ngubane, A Khathi(2019) Cardioprotective effects of a ruthenium (II) Schiff base complex in diet-induced prediabetic rats Diabetes, metabolic syndrome and obesity: targets and therapy 12, 217

LP Mabuza, MW Gamede, S Maikoo, IN Booysen, PS Ngubane, A Khathi (2019) Hepatoprotective effects of a ruthenium (II) schiff base complex in rats with diet-induced prediabetes

Current Therapeutic Research 91, 66-7

A.Ludidi^a M.C.Baloyi^aA.Khathi^aN.H.Sibiya^bP.S.Ngubane^a (2019).The effects of Momordica balsamina methanolic extract on haematological function in streptozotocin-induced diabetic rats: Effects on selected markers. Biomedicine & Pharmacotherapy. 166. 108925.   

Mlindeli Gamede, Lindokuhle Mabuza, Phikelelani Ngubane and .Andile Khath (2019). Plant-Derived Oleanolic Acid (OA) Ameliorates Risk Factors of Cardiovascular Diseases in a Diet-Induced Pre-Diabetic Rat Model: Effects on Selected Cardiovascular Risk Factors. Molecules. 24(2), 340.                                                                                                                       

Lindokuhle Patience Mabuza,¹ Mlindeli Wilkinson Gamede,¹ Sanam Maikoo,² Irvin Noel Booysen,² Phikelelani Siphosethu Ngubane,¹ and Andile Khathi¹(2019). Cardioprotective effects of a ruthenium (II) Schiff base complex in diet-induced prediabetic rats. Diabetes Metabolism Syndrome Obesety: Targets and therapy. 2019; 12: 217–223.     

Nomusa Mabuza, Phikelelani S. Ngubane  and Andile Khathi (2019). The changes in immune cell concentration during the progression of pre-diabetes to type 2 diabetes in a high-fat high-carbohydrate diet-induced pre-diabetic rat mode. Autoimmunity.

Anelisiwe Siboto, Ntethelelo Sibiya, Andile Khathi and Phikelelani Ngubane (2018). The Effects of Momordica balsamina Methanolic Extract on Kidney Function in STZ-Induced Diabetic Rats: Effects on Selected Metabolic Markers. Journal of Diabetes Research. 28: 1-8.            

Mlindeli Gamede, Lindokuhle Mabuza, Phikelelani Ngubane and Andile Khathi * (2018). The effects of Plant-Derived Oleanolic Acid on Selected Parameters of Glucose Homeostasis in a Diet-Induced Pre-Diabetic Rat Model. Molecules 23(4):794.                                                  

Lindokuhle Mabuza L, Mlindeli Wilkinson Gamede , Sanam Maikoo , Irvin Noel Booysen , Phikelelani Siphosethu Ngubane  and Andile Khathi (2018). “Effects of a ruthenium Schiff base complex on glucose homeostasis in diet-induced pre-diabetic rats. Molecules.                     

Sibiya, Ntethelelo, Ngubane, Phikelelani, Mabandla, Musa (2017). Cardio-protective effects of pectin-insulin patch in streptozotocin-induced diabetic rats. Journal of Diabetes. 9: 12.

Sibiya, Ntethelelo, Ngubane, Phikelelani, Mabandla, Musa (2017). The Ameliorative Effect of Pectin-Insulin Patch On Renal Injury in Streptozotocin-Induced Diabetic Rats. Kidney Blood Pressure Research.42: 530-540.                                                                                                                               

Ngubane PS1, Hadebe SI, Serumula MR, Musabayane CT (2015). The effects of transdermal insulin treatment of  streptozotocin-induced diabetic rats on kidney function and renal expression of glucose transporters. Renal Failure. 37 (1): 151-159                                                     

Hadebe, Silindile I.; Ngubane, Phikelelani S.; Serumula, Metse R. (2014). Transdermal Delivery of Insulin by Amidated Pectin Hydrogel Matrix Patch in Streptozotocin-Induced Diabetic Rats: Effects on Some Selected Metabolic Parameters PLOS ONE. 9: 7                      

Ngubane, Phikelelani S.; Masola, Bubuya; Musabayane, Cephas T.(2011). The Effects of Syzygium aromaticum-Derived Oleanolic Acid on Glycogenic Enzymes in Streptozotocin-Induced Diabetic Rats. Renal Failure. 33: 4: 434-439.