Discipline of Physiology

Academic Leader

A Khathi picture

Dr Andile Khathi

Academic Leader: Physiology
Tel: +27 (0)31 260 7585
E-mail: khathia@ukzn.ac.za

CampusWestville
Room E3-408
Department of Human Physiology
Research InterestsMetabolic syndrome, prediabetes and diabetes mellitus management. Identifying new clinical biomarkers for early diagnosis of endocrine disorders.
BiosketchDr Khathi joined the University of KwaZulu-Natal in April 2015 and was appointed as a Lecturer in the Discipline of Human Physiology at the School of Laboratory Medicine and Medical Sciences. He graduated with a Bachelor of Medical Science (Physiology) degree at UKZN in 2010 and completed his Honours of Medical Sciences cum laude in 2011. In 2013, his Masters study was upgraded to a PhD study and in 2015 he graduated with a Doctor of Philosophy (Physiology).
He is currently a co-leader of the endocrinology group which focuses on studying the origins of various endocrine disorders as well as trying to come up with alternative therapeutic approaches. He is actively involved in undergraduate teaching as well as the supervision of Honours, Masters and PhD students.
List of Publications1. Mzimela NC, Ngubane PS, Khathi A (2019). Investigating the changes in immune cells during the progression of pre-diabetes to type 2 diabetes in a high-fat high-carbohydrate diet-induced pre-diabetic rat model. Autoimmunity 52(1):27-36

2. Gamede MW, Mabuza LP, Ngubane PS, Khathi A (2019). Plant-derived oleanolic acid ameliorates markers associated with non-alcoholic fatty liver disease in a diet-induced pre-diabetes rat model. Diabetes, Metabolic syndrome and Obesity: Targets and Therapy. Accepted

3. Baloyi CM, Khathi A, Sibiya NH, Ngubane PS (2019). The Haematological Effects of Oleanolic Acid on Streptozocin-Induced Diabetic Rats: Effects on Selected Markers. Journal of Diabetes research. Accepted

4. Mabuza LP, Gamede MW, Maikoo S, Booysen IN, Ngubane PS, Khathi A (2019). Cardioprotective effects of a Ruthenium Schiff Base Complex on Glucose Homeostasis in Diet-Induced Pre-Diabetic Rats. Diabetes, Metabolic syndrome and Obesity: Targets and Therapy 12:217-223

5. Mabuza LP, Gamede MW, Maikoo S, Booysen IN, Ngubane PS, Khathi A (2019). Hepatoprotective effects of a ruthenium(II) Schiff base complex in diet-induced pre-diabetic rats. Current Therapeutic Research. Accepted
https://doi.org/10.1080/08916934.2019.1575820

6. Gamede MW, Mabuza LP, Ngubane PS, Khathi A. Plant-Derived Oleanolic Acid (OA) Ameliorates Risk Factors of Cardiovascular Diseases in a Diet-Induced Pre-Diabetic Rat Model: Effects on Selected Cardiovascular Risk Factors. Molecules 24(2):340

7. Luvuno M, Khathi A, Mabandla MV. Diet-induced prediabetes: effects on oxidative stress and inflammatory biomarkers as agents for vascular complications in renal function. PONTE. DOI: 10.21506/j.ponte.2019.2.9

8. Ludidi A, Baloyi MC, Sibiya NH, Khathi A, Ngubane PS (2019). The Effects of Momordica balsamina methanolic extract on haematological function in streptozotocin-induced diabetic rats: Effects on selected markers. Biomedicine & pharmacotherapy. DOI: 10.1016/j.biopha.2019.108925

9. Gamede MW, Mabuza LP, Ngubane PS, Khathi A (2018). The Effects of Plant-Derived Oleanolic Acid on Selected Parameters of Glucose Homeostasis in a Diet-Induced Pre-Diabetic Rat Model. Molecules 23(4), 794

10. Mabuza LP, Gamede MW, Maikoo S, Booysen IN, Ngubane PS, Khathi A (2018). Effects of a Ruthenium Schiff Base Complex on Glucose Homeostasis in Diet-Induced Pre-Diabetic Rats. Molecules 23(7), 1721

11. Siboto A, Sibiya NH, Khathi A, Ngubane PS (2018). The Effects of Momordica balsamina Methanolic Extract on Kidney Function in STZ-Induced Diabetic Rats: Effects on Selected Metabolic Markers. Journal of diabetes research. https://doi.org/10.1155/2018/7341242

12. Luvuno M, Khathi A, Mabandla MV (2018). Voluntary ingestion of a high-fat high-carbohydrate diet: a model for prediabetes. PONTE http://dx.doi.org/10.21506/j.ponte.2018.5.11

13. Luvuno M, Mbongwa HP, Khathi A. The effects of Syzygium aromaticum-derived triterpenes on gastrointestinal ghrelin expression in streptozotocin-induced diabetic rats. African Journal of African Traditional, complementary and Alternative Medicines. 13(4): 8-14

14. Khathi A, Mbatha B, Musabayane C (2014). The hypoglycaemic and antioxidant properties of oleanolic acid ameliorate blood pressure and kidney function of experimental animals. Endocrinology, diabetes and metabolism :38:224

15. Khathi A, Serumula MR, Myburg RB, Van Heerden FR, Musabayane CT (2013). Effects of Syzygium aromaticum-derived triterpenes on postprandial blood glucose in streptozotocin-induced diabetic rats following carbohydrate challenge. Plos One;8(11):e81632.

16. Khathi A, Masola B, Musabayane CT (2012). Effects of Syzygium aromaticum‐derived oleanolic acid on glucose transport and glycogen synthesis in the rat small intestine. Journal of Diabetes. 2012 DOI: 10.1111/j.1753-0407.2012.00230.x